Vice President J D Vance on Friday warned Iran not to "play" the US as he headed overseas for negotiations aimed at ending the war. President Donald Trump has tasked the member of his inner circle who has seemed to be the most reluctant defender of the six-week-old conflict with Iran to now find a resolution and stave off the US president's astonishing threat to wipe out its "whole civilisation".

Vance, who has long been skeptical of foreign military interventions and outspoken about the prospect of sending troops into open-ended conflicts, set off Friday to lead mediated talks with Iran in the Pakistani capital of Islamabad. "If the Iranians are willing to negotiate in good faith, we're certainly willing to extend the open hand," Vance told reporters before boarding Air Force Two to make his way to the talks in Pakistan.